Sandra Cooper, Preston’s foster carer, who looked after him for the first nine months of his life, said in court that she now felt “mistrustful and anxious” about any children leaving her care.
She said she and her husband were planning to retire but they felt they could no longer do so as they “could not sit back and enjoy ourselves knowing that other children were being abused, mistreated and could die”.
Ms Cooper added: “My husband Paul and I have continued to foster children to protect them. We are doing this for Preston, in his memory.”
Sentencing the men, Mr Justice Turner said Preston had been subjected to “unremitting abuse” and neglect before he was killed. He added that whole life orders were only given in cases of the most “extreme gravity”.
Addressing Varley, the judge continued: “This is a case of the most extreme gravity. You must stay in prison for the rest of your life. You will never be eligible for parole.”
He described the abuse of Preston as “sadistic” and said he had been subjected to “prolonged” incidents of “serious cruelty”.
Varley, who retched in the dock after being found guilty, showed no emotion as he was sentenced. He sat still and looked straight ahead with his hands folded in his lap.
Whole life orders are extremely rare, and mean defendants will never be released from prison.
In recent years, Lucy Letby, the child serial killer, Wayne Couzens, the Metropolitan Police officer who murdered Sarah Everard, and Kyle Clifford, who killed three members of the Hunt family, have been given whole life orders.

A Government spokesman said Varley and McGowan-Fazakerley were “evil abusers” who had exploited a vulnerable child.
“The public rightly demand answers about what went wrong, and we can assure them we will make sure anyone responsible for negligence faces consequences,” the spokesman added.
DCI Andy Fallows, of Lancashire Police, said Varley was “an evil and monstrous individual who sexually, physically and mentally abused a vulnerable baby for his own sadistic pleasure”.
He said McGowan-Fazakerley “did nothing to help Preston, and that the case was the “most extreme example of sordid and wicked behaviour by two completely remorseless human beings”.